Muscarinic slow excitation and muscarinic inhibition of synaptic transmission in the rat neostriatum.
نویسندگان
چکیده
منابع مشابه
M 1 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in the hippocampus in vitro
The effects of the cholinoceptor agonist, carbachol (CCh), were examined in the rat hippocampal slice preparation. Intracellular recordings from CA 1 pyramidal neurones revealed that CCh (1-3/~M) inhibited excitatory postsynaptic responses evoked by stimulation of the Schaffer collateral/commissural pathway while, at the same time, direct excitability was enhanced. Extracellularly, CCh produced...
متن کاملMuscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal gray.
The midbrain periaqueductal gray (PAG) is involved in organizing behavioral responses to threat, stress, and pain. These PAG functions are modulated by cholinergic agents. In the present study, we examined the cholinergic modulation of synaptic transmission in the PAG using whole-cell voltage-clamp recordings from rat midbrain slices. We found that the cholinergic agonist carbachol reduced the ...
متن کاملMuscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal grey
The midbrain periaqueductal grey (PAG) is involved in organizing behavioural responses to threat, stress and pain. These PAG functions are modulated by cholinergic agents. In the present study, we examined the cholinergic modulation of synaptic transmission in the PAG using whole-cell voltage-clamp recordings from rat midbrain slices. We found that the cholinergic agonist carbachol reduced the ...
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High-affinity muscarinic cholinergic receptors were detected in myelin purified from rat brain stem with use of the radioligands 3H-N-methylscopolamine (3H-NMS), 3H-quinuclidinyl benzilate (3H-QNB), and 3H-pirenzepine. 3H-NMS binding was also present in myelin isolated from corpus callosum. In contrast, several other receptor types, including alpha 1- and alpha 2-adrenergic receptors, present i...
متن کاملA model for pleiotropic muscarinic potentiation of fast synaptic transmission.
The predominant form of muscarinic excitation in the forebrain and in sympathetic ganglia arises from m1 receptors coupled to the G(q/11) signal transduction pathway. Functional components of this system have been most completely mapped in frog sympathetic B neurons. Presynaptic stimulation of the B neuron produces a dual-component muscarinic excitatory postsynaptic potential (EPSP) mediated by...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1986
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1986.sp016304